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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN14
All Species:
13.94
Human Site:
T459
Identified Species:
30.67
UniProt:
Q15678
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15678
NP_005392.2
1187
135261
T459
M
K
R
G
I
L
H
T
D
S
Q
S
Q
S
L
Chimpanzee
Pan troglodytes
XP_001171329
1187
135241
T459
M
K
R
G
I
L
H
T
D
S
Q
S
Q
S
L
Rhesus Macaque
Macaca mulatta
XP_001106167
1187
135194
T459
M
K
R
G
I
L
H
T
D
S
Q
S
Q
S
L
Dog
Lupus familis
XP_849236
1187
134903
A459
M
K
R
G
V
L
H
A
D
S
Q
S
Q
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q62130
1189
135012
A459
M
K
R
G
L
M
H
A
D
S
Q
S
R
S
L
Rat
Rattus norvegicus
Q62728
1175
133393
A465
L
N
R
G
M
V
H
A
D
R
H
S
H
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511302
1193
135259
T464
M
K
R
G
V
M
P
T
E
S
Q
S
Q
S
L
Chicken
Gallus gallus
XP_419419
1191
135566
M464
M
K
R
G
V
I
Q
M
D
S
Q
S
Q
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
Y154
S
R
P
D
P
L
V
Y
S
Q
P
E
I
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
E346
Y
Q
T
L
E
E
N
E
H
R
K
S
A
G
H
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
E470
N
P
S
L
T
N
N
E
K
V
R
A
H
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
95.6
N.A.
91.5
53.7
N.A.
87.9
84.9
N.A.
32.8
N.A.
N.A.
N.A.
24.7
34.5
Protein Similarity:
100
99.7
99.5
97.2
N.A.
95.6
70.7
N.A.
92.1
91.5
N.A.
48.1
N.A.
N.A.
N.A.
42
51.7
P-Site Identity:
100
100
100
86.6
N.A.
73.3
46.6
N.A.
73.3
73.3
N.A.
6.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
66.6
N.A.
93.3
86.6
N.A.
13.3
N.A.
N.A.
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
28
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
0
64
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
10
0
19
10
0
0
10
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
73
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
55
0
10
0
10
0
19
0
10
% H
% Ile:
0
0
0
0
28
10
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
64
0
0
0
0
0
0
10
0
10
0
0
0
0
% K
% Leu:
10
0
0
19
10
46
0
0
0
0
0
0
0
10
73
% L
% Met:
64
0
0
0
10
19
0
10
0
0
0
0
0
0
0
% M
% Asn:
10
10
0
0
0
10
19
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
10
0
10
0
0
0
10
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
10
0
0
10
64
0
55
0
10
% Q
% Arg:
0
10
73
0
0
0
0
0
0
19
10
0
10
10
0
% R
% Ser:
10
0
10
0
0
0
0
0
10
64
0
82
0
73
0
% S
% Thr:
0
0
10
0
10
0
0
37
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
28
10
10
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _